Histone Mutations and Cancer

Histone mutations sit at an important intersection of epigenetics and cancer biology. In Histone Mutations and Cancer, editors Dong Fang and Junhong Han bring together research on how changes to histone proteins—especially histone H3—relate to tumor development and potential therapeutic approaches.

From chromatin biology to oncohistones

The volume opens with the fundamentals of histone modification and the H3 family, giving readers context for understanding how altered histones can affect chromatin and gene expression. From there, its chapters examine mutations associated with brain and bone tumors, including H3K27M and H3G34 mutations.

Focused coverage of tumors and treatment research

Alongside discussions of histone mutations in brain and bone cancers, the book considers epigenetic-targeted treatments for H3K27M-mutant midline gliomas and the potential of histone lysine-to-methionine mutations as anticancer drug targets. The collection links molecular mechanisms with active questions in cancer research, including diagnosis and therapeutic investigation.

A specialist reference for cancer epigenetics

Part of Advances in Experimental Medicine and Biology, this concise, multi-author volume is intended chiefly for researchers and graduate students. It may also interest readers in basic and clinical oncology, epigenetics, and related biomedical research who want a focused overview of oncohistones and their relevance to tumors.

For readers studying how changes in chromatin biology intersect with cancer, this book offers a structured route from histone fundamentals to tumor-specific mutations and emerging treatment strategies.